ING2 anticorps (C-Term)

N° du produit ABIN374223

Détail du produit anti-ING2 anticorps

Antigène: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Épitope: C-Term

Reactivité: Humain, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ING2 est non-conjugé

Application: Western Blotting (WB)

Séquence: C-DKSTEKTKKD RRSR

Specificité: This antibody detetcs ING2 / ING1L at C-term.

Réactivité croisée (Details): Species reactivity (expected):CowSpecies reactivity (tested):Human

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogène: Peptide from C Terminus of the protein sequence according to NP_001555.1. Genename: ING2

Information d'application

Indications d'application: Pedeux et al, ING2 regulates the onset of replicative senescence by induction ofp300-dependent p53 acetylation. Mol Cell Biol.2005 Aug,25(15): 6639-48. PMID: 16024799
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Détails sur ING2

Antigène: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Autre désignation: ING2 / ING1L (ING2 Produits)

Synonymes: anticorps ING1L, anticorps p33ING2, anticorps 2810011M06Rik, anticorps Ing1l, anticorps Ing2b, anticorps P33ING2, anticorps ING2, anticorps INGX, anticorps wu:fe11c08, anticorps zgc:92346, anticorps ING1Lp, anticorps ing2, anticorps xing2, anticorps inhibitor of growth family member 2, anticorps inhibitor of growth family, member 2, anticorps inhibitor of growth family member 2 S homeolog, anticorps inhibitor of growth family member 2 L homeolog, anticorps ING2, anticorps Ing2, anticorps ing2.S, anticorps ing2, anticorps ing2.L

Sujet: This protein is similar to ING1, a tumor suppressor protein that can bind TP53, inhibit cell growth, and induce apoptosis. This protein binds phosphoinositides (PtdInPs) at its plant homeodomain (PHD) domain and it acts as a PtdInPs receptor. PtdInPs binding regulates the ability of this protein to activate TP53 and TP53-dependent apoptosis.Synonyms: Inhibitor of growth 1-like protein, Inhibitor of growth protein 2, p33ING2

ID gène: 3622

NCBI Accession: NP_001555

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling