ACTR1A anticorps (C-Term)

N° du produit ABIN374428

Détail du produit anti-ACTR1A anticorps

Antigène: ACTR1A (Alpha Centractin (ACTR1A))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ACTR1A est non-conjugé

Application: Western Blotting (WB)

Séquence: C-YEEDGARSIH RKT

Specificité: This antibody detects Centractin alpha at C-term.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, PigSpecies reactivity (tested):Human

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogène: Peptide from C Terminus of the protein sequence according to NP_005727.1 Genename: ACTR1A

Information d'application

Indications d'application: Peptide ELISA: Limit dilution 1: 1000. Western blot: 1-3 μg/mL. Approx.45 kDa band observed in Human Kidney lysates(calculated MW of 42.5 kDa according to NP_005727.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Détails sur ACTR1A

Antigène: ACTR1A (Alpha Centractin (ACTR1A))

Autre désignation: Centractin alpha (ACTR1A Produits)

Synonymes: anticorps ARP1, anticorps CTRN1, anticorps Arp1, anticorps alpha-Arp1, anticorps arp1, anticorps centractin, anticorps ctrn1, anticorps ACTR1A, anticorps ARP1 actin related protein 1 homolog A, anticorps ARP1 actin-related protein 1A, centractin alpha, anticorps ARP1 actin-related protein 1 homolog A, centractin alpha, anticorps ARP1 actin related protein 1 homolog A L homeolog, anticorps alpha-centractin, anticorps actin-2, anticorps ACTR1A, anticorps Actr1a, anticorps actr1a.L, anticorps actr1a, anticorps PTRG_02540, anticorps PAAG_06972, anticorps MCYG_01044, anticorps VDBG_00685, anticorps MGYG_00946, anticorps DICPUDRAFT_88548, anticorps PGTG_04034, anticorps Tsp_06409

Sujet: The actin-related protein ACTR1A, a member of the superfamily of actin-related proteins, is the major subunit of the dynactin complex, a key component of the cytoplasmic dynein motor machinery. The major components of the dynactin complex, consisting of at least ten polypeptides, include ACTR1A. ACTR1A, the most abundant subunit in the dynactin complex, is most similar to conventional actin (>50 % amino acid identity). The dynactin complex has been shown to localize to multiple structures within the cell, including membrane organelles, the centrosome, spindle poles, and spindle pole microtubules during mitosis and prometaphase kinetochores. It regulates dynein mediated vesicle movement on microtubules as well as spindle assembly and cell division. ACTR1A overexpression in cells results in aberrant spindle morphologies and cell cycle delay at prometaphase, suggesting a possible function of ACTR1A/dynactin complex in progression through the prometaphase of mitosis.Synonyms: ACTR1A, ARP1, Actin-RPV, CTRN1, Centrosome-associated actin homolog

ID gène: 10121

NCBI Accession: NP_005727

UniProt: P61163

Pathways: M Phase