KCNJ11 anticorps (Internal Region, N-Term)

N° du produit ABIN374886

Détail du produit anti-KCNJ11 anticorps

Antigène: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Épitope: Internal Region, N-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: C-AEDPAKPRYR ARQ

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium sulphate precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide from the internal region (near the N Terminus) of the protein sequence according to NP_000516.3 Genename: KCNJ11

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/32000. Western blot: 0.1-0.3 μg/mL. Approx 45-48 kDa band observed in Human Skeletal Musclelysates (calculated MW of 43.8 kDa according to NP_000516.3). Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Pancreas shows variablestaining across the islet of Langerhans.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.

Détails sur KCNJ11

Antigène: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Autre désignation: KCNJ11 (KCNJ11 Produits)

Synonymes: anticorps kir6.2, anticorps Kir6.2, anticorps mBIR, anticorps BIR, anticorps HHF2, anticorps IKATP, anticorps KIR6.2, anticorps PHHI, anticorps TNDM3, anticorps potassium voltage-gated channel subfamily J member 11, anticorps potassium inwardly-rectifying channel, subfamily J, member 11, anticorps potassium inwardly rectifying channel, subfamily J, member 11, anticorps KCNJ11, anticorps kcnj11, anticorps Kcnj11

Sujet: ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.Synonyms: ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K+ channel Kir6.2, KCNJ11, Potassium channel, inwardly rectifying subfamily J member 11

ID gène: 9606

UniProt: Q14654

Pathways: Negative Regulation of Hormone Secretion