F13A1 anticorps (Internal Region)

N° du produit ABIN374910

Détail du produit anti-F13A1 anticorps

Antigène: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Épitope: AA 703-717, Internal Region

Reactivité: Humain, Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp F13A1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to Factor XIIIa.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-HRKLIASMSSDSLRH, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/32000. Western Blot: 0.05 - 0.2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur F13A1

Antigène: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Autre désignation: Coagulation Factor XIIIa (F13A1) (F13A1 Produits)

Synonymes: anticorps F13a, anticorps f13a1, anticorps wu:fo83d04, anticorps zgc:153334, anticorps F13A1, anticorps F13A, anticorps 1200014I03Rik, anticorps AI462306, anticorps coagulation factor XIII A1 chain, anticorps coagulation factor XIII, A1 polypeptide b, anticorps coagulation factor XIII A chain, anticorps coagulation factor XIII, A1 subunit, anticorps F13a1, anticorps f13a1b, anticorps F13A1

Sujet: Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160 kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.Synonyms: Coagulation factor XIII A chain, F13A, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain

ID gène: 2162

NCBI Accession: NP_000120

UniProt: P00488