ERN1 anticorps (Internal Region)

N° du produit ABIN375027

Cet anticorps anti-ERN1 est un anticorps Chèvre Polyclonal détectant ERN1 dans WB. Adapté pour Humain, Souris, Rat et Chien. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour ERN1 anticorps (Internal Region) (ABIN375027)

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ERN1 anticorps

Épitope: Internal Region

Specificité: This antibody reacts to ERN1 / IRE1a.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine, Bovine and Swine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-PNAHGKIKAMISD, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-ERN1 (ABIN375027)

Lai, Li, Kuang, Cui, Yang, Sun, Liu, Chen, Yan, Wen: "PKCδ silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity." dans: Bioscience reports, Vol. 37, Issue 6, (2018) (PubMed).

Yokouchi, Hiramatsu, Hayakawa, Okamura, Du, Kasai, Takano, Shitamura, Shimada, Yao, Kitamura: "Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response." dans: The Journal of biological chemistry, Vol. 283, Issue 7, pp. 4252-60, (2008) (PubMed).

Détails sur ERN1

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Autre désignation: ERN1 / IRE1

Sujet: IRE1 is involved in myo inositol biosynthesis and is implicated as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus. It is a transmembrane protein that has both serine threonine kinase and endoribonuclease activities. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1

ID gène: 2081

NCBI Accession: NP_001424

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response