ESRRG anticorps (Internal Region)

N° du produit ABIN375117

Détail du produit anti-ESRRG anticorps

Antigène: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Épitope: Internal Region

Reactivité: Humain, Souris, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ESRRG est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to ESRRG. This antibody is expected to recognise isoform 1.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence CRMSNKDRHIDS, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/16000. Western Blot: 0.2 - 0.6 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ESRRG

Antigène: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Autre désignation: Estrogen-Related Receptor gamma (ESRRG Produits)

Synonymes: anticorps ERR3, anticorps ERRgamma, anticorps NR3B3, anticorps ESRRG, anticorps USH2A, anticorps DKFZp459J0417, anticorps err3, anticorps nr3b3, anticorps LOC100219115, anticorps errg, anticorps errgamma, anticorps esrrg, anticorps errb/g, anticorps esrrgl, anticorps errbeta/gamma, anticorps Errg, anticorps mKIAA0832, anticorps estrogen related receptor gamma, anticorps estrogen-related receptor gamma, anticorps estrogen-related receptor gamma a, anticorps estrogen-related receptor gamma b, anticorps ESRRG, anticorps esrrg, anticorps Esrrg, anticorps esrrga, anticorps esrrgb

Sujet: Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA binding domain, which has 68 % amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC1. ERR gamma has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre mRNA undergoes extensive alternative splicing at the 5 prime end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.Synonyms: ERR gamma-2, ERR3, ERRG2, ESRRG, Estrogen receptor-related protein 3, KIAA0832, NR3B3, Nuclear receptor subfamily 3 group B member 3

ID gène: 2104, 9606

UniProt: P62508

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway