CHRNA4 anticorps (Internal Region)

N° du produit ABIN375184

Détail du produit anti-CHRNA4 anticorps

Antigène: CHRNA4 (Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4))

Épitope: AA 29-43, Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp CHRNA4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-HVETRAHAEE RLLKK

Specificité: This antibody recognizes CHRNA4 (aa29-43). This antibody is expected Not to cross-react with the similar alpha 2 subunit.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Bovine, Canine.
Species reactivity (tested):Human, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Syntehtic peptide from the internal region of Human CHRNA4 (NP_000735.1) Genename: CHRNA4

Information d'application

Indications d'application: Peptide ELISA: 1/64000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CHRNA4

Antigène: CHRNA4 (Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4))

Autre désignation: Neuronal Acetylcholine Receptor Subunit alpha-4 (CHRNA4 Produits)

Synonymes: anticorps NACHRA4, anticorps BFNC, anticorps EBN, anticorps EBN1, anticorps NACHR, anticorps NACRA4, anticorps NARAC, anticorps Acra-4, anticorps Acra4, anticorps ENFL1, anticorps neuronal acetylcholine receptor subunit alpha-4, anticorps neuronal acetylcholine receptor subunit alpha-4-like, anticorps cholinergic receptor nicotinic alpha 4 subunit, anticorps cholinergic receptor, nicotinic, alpha 4b, anticorps cholinergic receptor, nicotinic, alpha polypeptide 4, anticorps CpipJ_CPIJ002434, anticorps LOC100368057, anticorps CHRNA4, anticorps chrna4b, anticorps Chrna4

Sujet: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. After binding acetylcholine, the nAChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in nACHR4 are the cause of autosomal dominant nocturnal frontal lobe epilepsy type 1 (ENFL1) also symbolized ADNFLE. ENFL1 is a disease characterized by clusters of motor seizures during sleep. Polymorphisms in this gene that provide protection against nicotine addiction have been described.Synonyms: CHRNA4, NACRA4, Nicotinic acetylcholine receptor subunit alpha 4

Poids moléculaire: 70.0 kDa (Human NP_000735.1) and 70.2 kDa (Rat NP_077330.1)

ID gène: 25590

NCBI Accession: NP_077330

UniProt: P09483

Pathways: Synaptic Membrane