JAK2 anticorps (C-Term)

N° du produit ABIN387982

Cet anticorps Lapin Polyclonal détecte spécifiquement JAK2 dans WB, FACS et IF. Il présente une réactivité envers Humain et Souris et a été mentionné dans 3+ publications.

Aperçu rapide pour JAK2 anticorps (C-Term) (ABIN387982)

Antigène: JAK2 (Janus Kinase 2 (JAK2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAK2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: RB02956

Détail du produit anti-JAK2 anticorps

Épitope: AA 1101-1132, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This JAK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1101-1132 amino acids from the C-terminal region of human JAK2.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-JAK2 (ABIN387982)

Feng, Chen, Wang, Cheng, Zou, Zhong, Xu: "Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 97, Issue 9, pp. 1008-1019, (2017) (PubMed).

Zhao, Li, Liao, Luo, Shi, Feng, Chen: "Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells." dans: International journal of molecular sciences, Vol. 16, Issue 11, pp. 27411-21, (2015) (PubMed).

Kanda, Watanabe: "Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes." dans: Endocrinology, Vol. 148, Issue 5, pp. 2317-25, (2007) (PubMed).

Détails sur JAK2

Antigène: JAK2 (Janus Kinase 2 (JAK2))

Autre désignation: JAK2

Sujet: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Poids moléculaire: 130674

ID gène: 3717

NCBI Accession: NP_004963

UniProt: O60674

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response