HGS anticorps (N-Term)

N° du produit ABIN388936

Détail du produit anti-HGS anticorps

Antigène: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Épitope: AA 256-286, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HGS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This HGS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the N-terminal region of human HGS.

Clone: RB4400

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur HGS

Antigène: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Autre désignation: HGS (HGS Produits)

Synonymes: anticorps HRS, anticorps Hrs, anticorps fi34f05, anticorps zgc:63492, anticorps wu:fi34f05, anticorps Hgr, anticorps ZFYVE8, anticorps CG2903, anticorps Dmel\\CG2903, anticorps HRS-2, anticorps Vps27, anticorps hrs, anticorps l(2)23AB5, anticorps l(2)23Ad, anticorps l(2)23Ad(Hrs), anticorps vps27, anticorps hgs, anticorps hepatocyte growth factor-regulated tyrosine kinase substrate, anticorps HGF-regulated tyrosine kinase substrate, anticorps Hepatocyte growth factor regulated tyrosine kinase substrate, anticorps hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog, anticorps HGS, anticorps Hgs, anticorps hgs, anticorps Hrs, anticorps hgs.L

Sujet: HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.

Poids moléculaire: 86192

ID gène: 9146

NCBI Accession: NP_004703

UniProt: O14964

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation