p21 anticorps (pThr57)

N° du produit ABIN389613

Cité dans 1 publication. Cet anticorps anti-p21 Polyclonal Lapin (Clone RB7643) (ABIN389613) détecte spécifiquement p21 dans IHC (p) et DB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour p21 anticorps (pThr57) (ABIN389613)

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p21 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Clone: RB7643

Détail du produit anti-p21 anticorps

Épitope: pThr57

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This P21CIP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T57 of human P21CIP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-p21 (ABIN389613)

Colleoni, Paternot, Pita, Bisteau, Coulonval, Davis, Raspé, Roger: "JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21." dans: Oncogene, Vol. 36, Issue 30, pp. 4349-4361, (2017) (PubMed).

Détails sur p21

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Autre désignation: p21Cip1

Sujet: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

Poids moléculaire: 18119

ID gène: 1026

NCBI Accession: NP_000380, NP_001207706, NP_001207707, NP_510867

UniProt: P38936

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy