c-MYC anticorps (pThr58)

N° du produit ABIN389723

Il existe 1 publication pour ce produit. L’anticorps anti-c-MYC Polyclonal Lapin est utilisé pour la détection de c-MYC dans des échantillons de Humain. Il a été validé pour WB et DB.

Aperçu rapide pour c-MYC anticorps (pThr58) (ABIN389723)

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MYC est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB11187

Détail du produit anti-c-MYC anticorps

Épitope: pThr58

Homologie: X, Zf, M, Rat, B, Pig, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MYC Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T58 of human MYC.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-c-MYC (ABIN389723)

Yeh, Lu, Ou, Cheng: "I?B kinases increase Myc protein stability and enhance progression of breast cancer cells." dans: Molecular cancer, Vol. 10, pp. 53, (2011) (PubMed).

Détails sur c-MYC

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Autre désignation: Myc Proto-Oncogene protein

Sujet: MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.

Poids moléculaire: 48804

ID gène: 4609

NCBI Accession: NP_002458

UniProt: P01106

Pathways: Signalisation p53, Cycle Cellulaire, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, L'effet Warburg