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PDK2 anticorps (C-Term)

PDK2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB03037 unconjugated
N° du produit ABIN391037
  • Antigène Voir toutes PDK2 Anticorps
    PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))
    Épitope
    • 15
    • 14
    • 11
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 378-407, C-Term
    Reactivité
    • 95
    • 54
    • 46
    • 10
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 89
    • 13
    Lapin
    Clonalité
    • 82
    • 20
    Polyclonal
    Conjugué
    • 44
    • 9
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PDK2 est non-conjugé
    Application
    • 86
    • 54
    • 44
    • 17
    • 14
    • 13
    • 9
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This PDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-407 amino acids from the C-terminal region of human PDK2.
    Clone
    RB03037
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PDK2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Hurd, Collins, Abakumova, Chouchani, Baranowski, Fearnley, Prime, Murphy, James: "Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species." dans: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35153-60, (2012) (PubMed).

    Love, LeBlanc, Inglis, Bradley, Choptiany, Heigenhauser, Peters: "The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity." dans: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 111, Issue 2, pp. 427-34, (2011) (PubMed).

    Dunford, Herbst, Jeoung, Gittings, Inglis, Vandenboom, LeBlanc, Harris, Peters: "PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation." dans: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 300, Issue 6, pp. R1487-93, (2011) (PubMed).

    Nicholls, Chu, Abbruzzese, Tremblay, Hardy: "Mechanism of a genetically encoded dark-to-bright reporter for caspase activity." dans: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24977-86, (2011) (PubMed).

    McClenaghan, Scullion, Mion, Hewage, Malthouse, Flatt, Newsholme, Brennan: "Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells." dans: Clinical science (London, England : 1979), Vol. 116, Issue 4, pp. 341-51, (2009) (PubMed).

    Sun, Zhou, Chang, McFate, Verma, Califano: "Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 476-84, (2009) (PubMed).

    Richards, Sardella, Schulte: "Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure." dans: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 295, Issue 3, pp. R979-90, (2008) (PubMed).

    Zhang, Ma, Sadana, Chowdhury, Gaillard, Wang, McDonnell, Unterman, Elam, Park: "Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression." dans: The Journal of biological chemistry, Vol. 281, Issue 52, pp. 39897-906, (2006) (PubMed).

    Xu, Han, Epstein, Liu: "Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets." dans: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 827-33, (2006) (PubMed).

    Churchill, Murriel, Chen, Mochly-Rosen, Szweda: "Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation." dans: Circulation research, Vol. 97, Issue 1, pp. 78-85, (2005) (PubMed).

  • Antigène
    PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))
    Autre désignation
    PDK2 (PDK2 Produits)
    Synonymes
    anticorps PDHK2, anticorps PDKII, anticorps Pdk, anticorps zgc:56209, anticorps PDK2, anticorps pyruvate dehydrogenase kinase 2, anticorps pyruvate dehydrogenase kinase, isoenzyme 2, anticorps pyruvate dehydrogenase kinase, isozyme 2b, anticorps PDK2, anticorps Pdk2, anticorps pdk2b
    Sujet
    PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
    Poids moléculaire
    46154
    ID gène
    5164
    NCBI Accession
    NP_001186827, NP_001186828, NP_002602
    UniProt
    Q15119
    Pathways
    Signalisation PI3K-Akt, Signalisation RTK, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg
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