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PDK2 anticorps

PDK2 Reactivité: Humain WB, IHC (p), FACS Hôte: Lapin Polyclonal RB23089 unconjugated
N° du produit ABIN653784
  • Antigène Voir toutes PDK2 Anticorps
    PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))
    Reactivité
    • 95
    • 54
    • 46
    • 10
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 89
    • 13
    Lapin
    Clonalité
    • 82
    • 20
    Polyclonal
    Conjugué
    • 44
    • 9
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PDK2 est non-conjugé
    Application
    • 86
    • 54
    • 44
    • 17
    • 14
    • 13
    • 8
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PDK2 antibody is generated from rabbits immunized with recombinant protein of human PDK2.
    Clone
    RB23089
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PDK2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Qvit, Disatnik, Sho, Mochly-Rosen: "Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo." dans: Journal of the American Chemical Society, Vol. 138, Issue 24, pp. 7626-35, (2018) (PubMed).

    Qvit, Joshi, Cunningham, Ferreira, Mochly-Rosen: "Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death." dans: The Journal of biological chemistry, Vol. 291, Issue 26, pp. 13608-21, (2016) (PubMed).

    Le Page, Rider, Lewis, Ball, Clarke, Johansson, Carr, Heather, Tyler: "Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study." dans: Diabetes, Vol. 64, Issue 8, pp. 2735-43, (2015) (PubMed).

    Sun, Chang, Fu, Liu, Califano: "Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1? stabilization." dans: PLoS ONE, Vol. 6, Issue 1, pp. e16207, (2011) (PubMed).

  • Antigène
    PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))
    Autre désignation
    PDK2 (PDK2 Produits)
    Synonymes
    anticorps PDHK2, anticorps PDKII, anticorps Pdk, anticorps zgc:56209, anticorps PDK2, anticorps pyruvate dehydrogenase kinase 2, anticorps pyruvate dehydrogenase kinase, isoenzyme 2, anticorps pyruvate dehydrogenase kinase, isozyme 2b, anticorps PDK2, anticorps Pdk2, anticorps pdk2b
    Sujet
    PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
    Poids moléculaire
    46154
    ID gène
    5164
    NCBI Accession
    NP_001186827, NP_001186828, NP_002602
    UniProt
    Q15119
    Pathways
    Signalisation PI3K-Akt, Signalisation RTK, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg
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