Aromatase anticorps (C-Term)

N° du produit ABIN2841671

Détail du produit anti-Aromatase anticorps

Antigène: Aromatase (CYP19A1) (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1))

Épitope: AA 453-485, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aromatase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Aromatase (CYP19A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-485 amino acids from the C-terminal region of human Aromatase (CYP19A1).

Clone: RB14708

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-Aromatase (ABIN2841671)

Ding, Li, Wang, Wang, Wu, Chen, Lv, Wang, Huang: "Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics." dans: Stem cell research & therapy, Vol. 8, Issue 1, pp. 173, (2018) (PubMed).

Licznerska, Szaefer, Wierzchowski, Sobierajska, Baer-Dubowska: "Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation." dans: Molecular and cellular biochemistry, Vol. 425, Issue 1-2, pp. 169-179, (2017) (PubMed).

Détails sur Aromatase

Antigène: Aromatase (CYP19A1) (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1))

Autre désignation: Aromatase (CYP19A1) (CYP19A1 Produits)

Synonymes: anticorps ARO, anticorps ARO1, anticorps CPV1, anticorps CYAR, anticorps CYP19, anticorps CYPXIX, anticorps P-450AROM, anticorps Aromatase, anticorps Cyp19, anticorps Cyp19a, anticorps p450arom, anticorps P450 arom, anticorps aro, anticorps cyp19, anticorps cyp19a, anticorps p450arom-A, anticorps P450AROM, anticorps Ar, anticorps ArKO, anticorps Int-5, anticorps Int5, anticorps CYP19P1, anticorps CYP19A1, anticorps CYP19a1, anticorps P450aromA, anticorps ar1, anticorps cypXIX, anticorps etID309862.18, anticorps zgc:136541, anticorps AroB, anticorps CYP19a2, anticorps P450aromB, anticorps cyp19b, anticorps zgc:92614, anticorps cyp19a1, anticorps cytochrome P450 family 19 subfamily A member 1, anticorps cytochrome P450, family 19, subfamily a, polypeptide 1, anticorps cytochrome P450 family 19 subfamily A member 1 L homeolog, anticorps aromatase, anticorps cytochrome P450 aromatase, anticorps cytochrome P450, family 19, subfamily A, polypeptide 1, anticorps cytochrome P450 19A1, anticorps cytochrome P450, family 17, subfamily A, polypeptide 1, anticorps cytochrome P450, family 19, anticorps cytochrome P450, family 19, subfamily A, polypeptide 1a, anticorps cytochrome P450, family 19, subfamily A, polypeptide 1b, anticorps cytochrome P450 19A1-like, anticorps CYP19A1, anticorps Cyp19a1, anticorps cyp19a1.L, anticorps SAV_2383, anticorps pfcyp19b-tstr, anticorps CYP19, anticorps cyp19a1a, anticorps cyp19a1b, anticorps LOC101174651

Sujet: CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity, the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

Poids moléculaire: 57883

ID gène: 1588

NCBI Accession: NP_000094, NP_112503

UniProt: P11511

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis