CTDSP1 anticorps (C-Term)

N° du produit ABIN392888

Détail du produit anti-CTDSP1 anticorps

Antigène: CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))

Épitope: AA 235-261, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTDSP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This CTDSP1-V250 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-261 amino acids from the C-terminal region of human CTDSP1-V250.

Clone: RB5996

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur CTDSP1

Antigène: CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))

Autre désignation: CTDSP1 (CTDSP1 Produits)

Synonymes: anticorps CTDSP1, anticorps NIF3, anticorps NLI-IF, anticorps NLIIF, anticorps SCP1, anticorps fj83f12, anticorps im:7141428, anticorps wu:fj83f12, anticorps zgc:113169, anticorps GIP, anticorps Nif3, anticorps CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1, anticorps CTD small phosphatase 1, anticorps carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, anticorps CTDSP1, anticorps Ctdsp1, anticorps ctdsp1, anticorps HCAG_04820, anticorps CTRG_06220

Sujet: CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF, 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.

Poids moléculaire: 29203

ID gène: 58190

NCBI Accession: NP_001193807, NP_067021, NP_872580

UniProt: Q9GZU7