AGAP2 anticorps (Internal Region)

N° du produit ABIN452299

Détail du produit anti-AGAP2 anticorps

Antigène: AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp AGAP2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to CENTG1.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-QASLDSIREAVINSQ, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur AGAP2

Antigène: AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

Autre désignation: AGAP2 / CENTG1 (AGAP2 Produits)

Synonymes: anticorps zgc:153779, anticorps CENTG1, anticorps GGAP2, anticorps PIKE, anticorps Centg1, anticorps mKIAA0167, anticorps Pike, anticorps ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, anticorps AGAP2, anticorps agap2, anticorps Agap2

Sujet: Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity. PIKE exists in multiple isoforms, a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes. In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis.Synonyms: Arf-GAP GTPase ANK repeat and PH domain-containing protein 2, Centaurin-gamma-1, GGAP2, GTP-binding and GTPase-activating protein 2, KIAA0167, PIKE, Phosphatidylinositol-3-kinase enhancer

ID gène: 116986

NCBI Accession: NP_055585

UniProt: Q99490