KCNQ4 anticorps (AA 2-77)

N° du produit ABIN452410

Détail du produit anti-KCNQ4 anticorps

Antigène: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Épitope: AA 2-77

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KCNQ4 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Specificité: This antibody detects KCNQ4 K+ Channel at ~77 kDa.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Attributs du produit: Synonyms: KCNQ4, Voltage-gated potassium channel subunit Kv7.4, Potassium channel subunit alphaKvLQT4, KQT-like 4, Potassium voltage-gated channel subfamily KQT member 4

Purification: Protein G chromatography

Immunogène: Fusion protein amino acid 2-77 of human KCNQ4 (Kv7. 4, KvLQT4)

Clone: S43-6

Isotype: IgG1

Information d'application

Indications d'application: Western blot: 1 - 10 μg/mL (if results are off, try using the lysate without boiling). Immunoprecipitation. Immunocytochemistry: 0.1 - 1.0 μg/mL (Perox).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol and 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur KCNQ4

Antigène: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Autre désignation: KCNQ4 (KCNQ4 Produits)

Synonymes: anticorps KCNQ4, anticorps k(v)7.4, anticorps kv7.4, anticorps DFNA2, anticorps DFNA2A, anticorps KV7.4, anticorps potassium voltage-gated channel subfamily Q member 4, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 4, anticorps potassium voltage-gated channel, subfamily Q, member 4, anticorps KCNQ4, anticorps kcnq4, anticorps Kcnq4

Sujet: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (3), particularly in sensory cells of the cochlea (4). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug (5).Synonyms: KCNQ4, KQT-like 4, Potassium channel subunit alpha KvLQT4, Potassium voltage-gated channel subfamily KQT member 4, Voltage-gated potassium channel subunit Kv7.4

ID gène: 9132

UniProt: P56696

Pathways: Sensory Perception of Sound