Ghrelin anticorps (C-Term)

N° du produit ABIN452691

Détail du produit anti-Ghrelin anticorps

Antigène: Ghrelin (GHRL)

Épitope: C-Term

Reactivité: Humain, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Ghrelin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Specificité: This antibody is expected to recognise all reported isoforms.

Réactivité croisée (Details): Species reactivity (tested):Human, Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence C-QDILWEEAKEAPADK, from the C Terminus of the protein sequence according to NP_057446.1, NP_001128413.1, NP_001128416.1, NP_001128417.1, NP_001128418.1.

Information d'application

Indications d'application: Peptide ELISA: Detection Limit: 1/8000. Immunohistochemistry: 2-5 μg/mL. In paraffin embedded Human Placenta shows stainingof trophoblast cytoplasm.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur Ghrelin

Antigène: Ghrelin (GHRL)

Autre désignation: Ghrelin / GHRL (GHRL Produits)

Synonymes: anticorps 2210006E23Rik, anticorps Ghr, anticorps MTLRP, anticorps MTLRPAP, anticorps m46, anticorps Gh1-1, anticorps GRHL, anticorps MTLRP-AP, anticorps GHR, anticorps ghrelin, anticorps ghrelin and obestatin prepropeptide, anticorps ghrelin/obestatin prepropeptide, anticorps Ghrl, anticorps GHRL, anticorps ghrl

Sujet: Ghrelin was originally discovered as a preprohormone that stimulates the release of growth hormone from the anterior pituitary. Recent studies have shown that ghrelin, in concert with other hormones, helps to control both appetite and energy balance. The synthesis of Ghrelin takes place predominantly in epithelial cells of the stomach, although it is also produced in smaller quantities in the placenta, kidney, pituitary and hypothalamus. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release from the pituitary. It has an appetite stimulating effect, induces adiposity, and stimulates gastric acid secretion, and it is involved in growth regulation. Ghrelin is synthesized as a preprohormone (13 kDa), then proteolytically processed to yield a 28 amino acid peptide (3 kDa). Obestatin, an appetite suppressing peptide hormone, is also produced in the process. An interesting and unique modification is imposed on the ghrelin hormone during synthesis in the form of octanoic acid bound to one of its amino acids. This modification is necessary for biological activity.Synonyms: Appetite-regulating hormone, Ghrelin-27, Ghrelin-28, Growth hormone secretagogue, Growth hormone-releasing peptide, M46 protein, MTLRP, Motilin-related peptide, Obestatin

ID gène: 51738

NCBI Accession: NP_001128413

UniProt: Q9UBU3

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour