CACNA1A
Reactivité: Rat
ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot: 1/400. Positive Control: Rat brain lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
Phosphate Buffered Saline with 0.08 % Sodium Azide as preservative.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.Synonyms: Brain calcium channel I, CACH4, CACN3, CACNL1A4, Calcium channel L type alpha-1 polypeptide isoform 4, Cav2.1, Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-gated calcium channel subunit alpha