CD46 anticorps
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- Antigène Voir toutes CD46 Anticorps
- CD46
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD46 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- Reacts with human 44 kDa CD46 protein
- Réactivité croisée (Details)
- Diffuse and duplicated bands can be seen due to the glycosylation of CD46.
- Purification
- Purified (protein A)
- Immunogène
- Recombinant CD46 protein
- Clone
- 3F1
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD46 Anticorps primaire
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- Indications d'application
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA1:20 000 - 1:100 000 IHC-P10 μg/mL WB1:2000 - 1:10000 - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Must be reconstituted in distilled water.
- Concentration
- 1 mg/mL
- Buffer
- PBS
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Date de péremption
- 24 months
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- Antigène
- CD46
- Autre désignation
- CD46 / Membrane Cofactor Protein (CD46 Produits)
- Synonymes
- anticorps AHUS2, anticorps MCP, anticorps MIC10, anticorps TLX, anticorps TRA2.10, anticorps Mcp, anticorps CD46, anticorps CD46 molecule, anticorps CD46 antigen, complement regulatory protein, anticorps CD46 molecule, complement regulatory protein, anticorps membrane cofactor protein-like, anticorps CD46, anticorps Cd46, anticorps LOC100341359, anticorps LOC103789310
- Sujet
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- ID gène
- 4179
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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