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EEA1 anticorps

EEA1 Reactivité: Humain, Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN4903538
  • Antigène Voir toutes EEA1 Anticorps
    EEA1 (Early Endosome Antigen 1 (EEA1))
    Reactivité
    • 77
    • 35
    • 30
    • 16
    • 9
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 53
    • 19
    • 3
    • 2
    • 1
    Lapin
    Clonalité
    • 59
    • 19
    Polyclonal
    Conjugué
    • 46
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EEA1 est non-conjugé
    Application
    • 42
    • 19
    • 14
    • 13
    • 13
    • 12
    • 10
    • 8
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Attributs du produit
    EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7).1.Mu, F.T. et al. (1995) J. Biol. Chem. 270, 13503-13511.2.Christoforidis, S. et al. (1999) Nature 397, 621-625.3.Gaullier, J.M. et al. (1998) Nature 394, 432-433.4.Patki, V. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 7326-7330.5.Lawe, D.C. et al. (2003) Mol. Biol. Cell 14, 2935-2945.6.Simonsen, A. et al. (1998) Nature 394, 494-498.7.McBride, H.M. et al. (1999) Cell 98, 377-386.
    Purification
    Affinity purification
    Immunogène
    Recombinant Protein of human EEA1.
    Isotype
    IgG
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  • Indications d'application
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C.
  • Antigène
    EEA1 (Early Endosome Antigen 1 (EEA1))
    Autre désignation
    EEA1 (EEA1 Produits)
    Synonymes
    anticorps MST105, anticorps MSTP105, anticorps ZFYVE2, anticorps im:7151048, anticorps si:ch211-276p10.2, anticorps A430109M19Rik, anticorps B230358H09Rik, anticorps early endosome antigen 1, anticorps early endosome antigen 1 S homeolog, anticorps EEA1, anticorps eea1, anticorps Eea1, anticorps eea1.S
    ID gène
    8411
    UniProt
    Q15075
    Pathways
    Toll-Like Receptors Cascades
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