EEA1 anticorps
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- Antigène Voir toutes EEA1 Anticorps
- EEA1 (Early Endosome Antigen 1 (EEA1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EEA1 est non-conjugé
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Application
- Western Blotting (WB)
- Attributs du produit
- EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7).1.Mu, F.T. et al. (1995) J. Biol. Chem. 270, 13503-13511.2.Christoforidis, S. et al. (1999) Nature 397, 621-625.3.Gaullier, J.M. et al. (1998) Nature 394, 432-433.4.Patki, V. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 7326-7330.5.Lawe, D.C. et al. (2003) Mol. Biol. Cell 14, 2935-2945.6.Simonsen, A. et al. (1998) Nature 394, 494-498.7.McBride, H.M. et al. (1999) Cell 98, 377-386.
- Purification
- Affinity purification
- Immunogène
- Recombinant Protein of human EEA1.
- Isotype
- IgG
- Top Product
- Discover our top product EEA1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C.
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- Antigène
- EEA1 (Early Endosome Antigen 1 (EEA1))
- Autre désignation
- EEA1 (EEA1 Produits)
- Synonymes
- anticorps MST105, anticorps MSTP105, anticorps ZFYVE2, anticorps im:7151048, anticorps si:ch211-276p10.2, anticorps A430109M19Rik, anticorps B230358H09Rik, anticorps early endosome antigen 1, anticorps early endosome antigen 1 S homeolog, anticorps EEA1, anticorps eea1, anticorps Eea1, anticorps eea1.S
- ID gène
- 8411
- UniProt
- Q15075
- Pathways
- Toll-Like Receptors Cascades
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