GRIA4 anticorps

N° du produit ABIN4903821

Détail du produit anti-GRIA4 anticorps

Antigène: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIA4 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). AMPARs that lack GluR 2 are permeable to calcium, in contrast to GluR 2-containing AMPARs (2). Post-transcriptional modifications (alternative splicing, nuclear RNA editing) and post-translational modifications (glycosylation, phosphorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer's, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1).GluR 4 containing AMPA receptors are found in synapses and GluR 4 delivery to synapses and cell surface expression is mediated through phosphorylation of Ser842 by PKA or PKC (3).

Purification: Affinity purification

Immunogène: Recombinant protein of human GLUR4.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-1:4000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur GRIA4

Antigène: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Autre désignation: GRIA4 (GRIA4 Produits)

Synonymes: anticorps GLUR4, anticorps GLUR4C, anticorps GLURD, anticorps GluA4, anticorps GluR4, anticorps GluR4d, anticorps GLUR4/D, anticorps glur4, anticorps GluR-D, anticorps Glur-4, anticorps Glur4, anticorps Gluralpha4, anticorps spkw1, anticorps DKFZp459P0616, anticorps glur4a, anticorps gria4, anticorps iGluR4, anticorps ZfGluR4b, anticorps fj46g06, anticorps glur4b, anticorps wu:fj46g06, anticorps glutamate ionotropic receptor AMPA type subunit 4, anticorps glutamate receptor, ionotropic, AMPA 4, anticorps glutamate receptor, ionotropic, AMPA4 (alpha 4), anticorps glutamate receptor, ionotropic, AMPA 4a, anticorps glutamate receptor, ionotropic, AMPA 4b, anticorps GRIA4, anticorps gria4, anticorps Gria4, anticorps gria4a, anticorps gria4b

ID gène: 2893

UniProt: P48058

Pathways: Signalisation PI3K-Akt