Desmoglein 1 anticorps (Internal Region)

N° du produit ABIN4949603

Détail du produit anti-Desmoglein 1 anticorps

Antigène: Desmoglein 1 (DSG1)

Épitope: Internal Region

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogène: A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the Desmoglein 1 antibody.

Clone: DSG1-1733

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Desmoglein 1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: Desmoglein 1 / DSG1 (DSG1 Produits)

Synonymes: anticorps CDHF4, anticorps DG1, anticorps DSG, anticorps PPKS1, anticorps SPPK1, anticorps DSG-1, anticorps DSG1, anticorps Dsg1b, anticorps Dsg1c, anticorps desmoglein 1, anticorps desmoglein 4, anticorps DSG1, anticorps DSG4, anticorps Dsg1

Sujet: Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Pathways: Cell-Cell Junction Organization