TSHR, A Chain anticorps

N° du produit ABIN4949910

Détail du produit anti-TSHR, A Chain anticorps

Antigène: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TSHR, A Chain est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogène: Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.

Clone: SPM223

Isotype: IgG1

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSHR antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 1-2 μg/mL,IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the TSHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur TSHR, A Chain

Antigène: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Autre désignation: Thyroid Stimulating Hormone Receptor / TSHR (alpha chain) (TSHR, A Chain Produits)

Sujet: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.