TSHR, A Chain anticorps (CF®647)

N° du produit ABIN6154145

Détail du produit anti-TSHR, A Chain anticorps (CF®647)

Antigène: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TSHR, A Chain est conjugé à/à la CF®647

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Fonction: Mouse Monoclonal anti-TSH Receptor, A chain (TSHRA/1402), CF647 Conjugate

Attributs du produit: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: A-Chain protein|Recombinant human TSHR

Clone: TSHRA-1402

Isotype: IgG kappa

Information d'application

Indications d'application: Immunohistology (formalin) 0.5-1 μg/mL

• Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA
•   pH 9.0
• or 10 mM citrate buffer
•   pH 6.0
• for 10-20 min followed by cooling at RT for 20 min
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Immunofluorescence 1-2 μg/mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

293T Cells. Thyroid gland

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur TSHR, A Chain

Antigène: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Autre désignation: TSH Receptor, A chain (TSHR, A Chain Produits)

Sujet: CHNG1, hTSHRI, LGR3, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, TSHR

Poids moléculaire: 62 kDa

ID gène: 7253, 160411

UniProt: P16473