Aquaporin 4 anticorps

N° du produit ABIN4950190

Détail du produit anti-Aquaporin 4 anticorps

Antigène: Aquaporin 4 (AQP4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogène: Amino acids KPGVVHVIDVDRGEEKKGKDQSGEVLSSV of human Aquaporin 4 were used as the immunogen for the AQP4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the AQP4 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Frozen): 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the AQP4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Aquaporin 4

Antigène: Aquaporin 4 (AQP4)

Autre désignation: Aquaporin 4 / AQP4 (AQP4 Produits)

Synonymes: anticorps zgc:100922, anticorps si:ch211-192k9.1, anticorps AQP4, anticorps LOC100232616, anticorps HMIWC2, anticorps MIWC, anticorps WCH4, anticorps AQP-4, anticorps AQP4.M23, anticorps MIWC2, anticorps Miwc, anticorps aquaporin-4, anticorps aquaporin 4, anticorps aquaporin 4 L homeolog, anticorps aqp4, anticorps AQP4, anticorps aqp4.L, anticorps Aqp4

Sujet: Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. The gene of AQP4 is mapped to 18q11.2-q12.1. Similar to other aquaporins, the AQP4 gene is composed of 4 exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alternative coding initiation sequence (designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0, the next 11 amino acids and M23 are encoded by exon 1. AQP4 is expressed in astrocytes and is upregulated by direct insult to the central nervous system. And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier.

UniProt: P55087

Pathways: Sensory Perception of Sound