GRB2 anticorps (AA 89-118)

N° du produit ABIN3031114

Cet anticorps Lapin Polyclonal détecte spécifiquement GRB2 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour GRB2 anticorps (AA 89-118) (ABIN3031114)

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-GRB2 anticorps

Épitope: AA 89-118

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Xenopus

Purification: Purified

Immunogène: A portion of amino acids 89-118 from the human protein was used as the immunogen for this GRB2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the GRB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4°C for up to one month. For long term, aliquot the GRB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur GRB2

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Autre désignation: GRB2

Sujet: GRB2 is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. [UniProt]

UniProt: P62993

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation