Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
Restrictions
For Research Use only
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Aliquot the BMPR1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Antigène
BMPR1B
(Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))
anticorps ALK6, anticorps BMPR-IB, anticorps FecB, anticorps alk-6, anticorps alk6, anticorps cdw293, anticorps alk6b, anticorps zgc:172219, anticorps BMPR1B, anticorps AI385617, anticorps ALK-6, anticorps AV355320, anticorps Acvrlk6, anticorps Alk6, anticorps BMPR-1B, anticorps CFK-43a, anticorps SKR6, anticorps BR1b, anticorps alk6tr, anticorps bmpr1b, anticorps zALK-6, anticorps zgc:92220, anticorps CDw293, anticorps BMP15, anticorps BMPRIB, anticorps RPK-1, anticorps bone morphogenetic protein receptor type 1B, anticorps bone morphogenetic protein receptor, type IBb, anticorps bone morphogenetic protein receptor, type 1B, anticorps bone morphogenetic protein receptor, type IBa, anticorps BMPR1B, anticorps bmpr1b, anticorps bmpr1bb, anticorps Bmpr1b, anticorps bmpr1ba
Sujet
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.