HLA-A anticorps (AA 70-99)

N° du produit ABIN3031678

Détail du produit anti-HLA-A anticorps

Antigène: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Épitope: AA 70-99

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-A est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Expected species reactivity: Human

Purification: Purified

Immunogène: A portion of amino acids 70-99 from the human protein was used as the immunogen for this HLA-A antibody.

Clone: 7G7F9

Isotype: IgG1

Information d'application

Indications d'application: Titration of the HLA-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the HLA-A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur HLA-A

Antigène: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Autre désignation: HLA-A (HLA-A Produits)

Synonymes: anticorps HLAA, anticorps major histocompatibility complex, class I, A, anticorps HLA-A

Sujet: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

UniProt: P04439

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints