SUMO4 anticorps (Met55Val-Mutant)

N° du produit ABIN3032655

Détail du produit anti-SUMO4 anticorps

Antigène: SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))

Épitope: Met55Val-Mutant

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUMO4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Antigen affinity purified

Immunogène: This SUMO4 antibody was produced from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SUMO4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SUMO4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SUMO4

Antigène: SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))

Autre désignation: SUMO4 (SUMO4 Produits)

Synonymes: anticorps IDDM5, anticorps SMT3H4, anticorps SUMO-4, anticorps dJ281H8.4, anticorps small ubiquitin-like modifier 4, anticorps small ubiquitin-related modifier 4, anticorps SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), anticorps SUMO4, anticorps sumo4

Sujet: SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.

UniProt: Q6EEV6