GLP2R anticorps (Extracellular Domain, N-Term)

N° du produit ABIN497997

Détail du produit anti-GLP2R anticorps

Antigène: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Épitope: Extracellular Domain, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLP2R est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Reacts with Glucagon-Like Peptide 2 Receptor (GLP2R).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide corresponding to N-terminal extracellular domain of Human GLP2R. .Remarks: The immunizing peptide shows 81% identity (87% similarity) with Rat.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Formalin Fixed Paraffin Embedded Tissues: 5-10 μg/mL(Requires pretreatment with Proteinase K).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.6 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Détails sur GLP2R

Antigène: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Autre désignation: GLP2 Receptor (GLP2R Produits)

Synonymes: anticorps 9530092J08Rik, anticorps GLP-2, anticorps glucagon like peptide 2 receptor, anticorps glucagon-like peptide 2 receptor, anticorps GLP2R, anticorps Glp2r

Sujet: GLP2R, a Glucagon Receptor, is closely related to the Glucagon Receptor and to the GLP1 Receptor. The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides cosecreted from gut endocrine cells in response to nutrient ingestion. The actions of GLP-2 are mediated by the GLP-2 receptor expressed on subsets of enteric nerves and enteroendocrine cells in the stomach and small and large intestine. Activation of GLP2R signaling promotes expansion of the mucosal epithelium indirectly via activation of growth and anti-apoptotic pathways. GLP2R, through its ligand glucagon-like peptide 2 (GLP2), has been shown to prevent intestinal hypoplasia resulting from total parenteral nutrition. GLP2R has been reported primarily in the gastrointestinal tract, including intestine and stomach. In rats, GLPR2 has been shown in brain and lung. An EST has been isolated from a lung cancer library.Synonyms: GLP-2-R, GLP-2R, GLP2R, Glucagon-like peptide 2 receptor

ID gène: 9340

NCBI Accession: NP_004237

UniProt: O95838

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Feeding Behaviour