NR1I3 anticorps

N° du produit ABIN498342

Détail du produit anti-NR1I3 anticorps

Antigène: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1I3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of MB67 protein. (region surrounding Thr102)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NR1I3

Antigène: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Autre désignation: NR1I3 (NR1I3 Produits)

Synonymes: anticorps AA209988, anticorps AI551208, anticorps CAR, anticorps CAR-beta, anticorps Care2, anticorps ESTM32, anticorps MB67, anticorps CAR1, anticorps CXR, anticorps nuclear receptor subfamily 1 group I member 3, anticorps nuclear receptor subfamily 1, group I, member 3, anticorps NR1I3, anticorps Nr1i3

Sujet: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: CAR, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, MB67, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67

Poids moléculaire: approx. 35 kDa

ID gène: 9970

NCBI Accession: NP_001070948

UniProt: Q14994

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway