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ARHGEF2 anticorps
ARHGEF2
Reactivité: Humain, Souris, Rat
WB
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-ARHGEF2 anticorps
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Antigène
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ARHGEF2
(rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
Reactivité
Toutes les réactivités sur ARHGEF2 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur ARHGEF2 Anticorps
Lapin
Clonalité
Toutes les clonalités sur ARHGEF2 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers ARHGEF2 Anticorps
Cet anticorp ARHGEF2 est non-conjugé
Application
Tous les applications à travers ARHGEF2 Anticorps.
Western Blotting (WB)
Specificité
This antibody detects endogenous levels of ARHGEF2 protein. (region surrounding Pro881)
Réactivité croisée (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Pureté
> 95 % by SDS-PAGE
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Information d'application
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Indications d'application
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur ARHGEF2
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Antigène
ARHGEF2
(rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
Autre désignation
ARHGEF2 (ARHGEF2 Produits )
Synonymes
anticorps MGC82333, anticorps MGC86214, anticorps MGC75855, anticorps AA408978, anticorps GEF, anticorps GEF-H1, anticorps GEFH1, anticorps LFP40, anticorps Lbcl1, anticorps Lfc, anticorps P40, anticorps mKIAA0651, anticorps GEF-H1/LFC, anticorps Rho/Rac guanine nucleotide exchange factor 2, anticorps Rho/Rac guanine nucleotide exchange factor 2 S homeolog, anticorps rho/rac guanine nucleotide exchange factor (GEF) 2, anticorps ARHGEF2, anticorps arhgef2.S, anticorps arhgef2, anticorps Arhgef2
Sujet
GEFs catalyze the release of GDP from inactive Ras proteins to ena-ble GTP binding. Lfc (also designated Rho/Rac guanine nucleotide exchange factor 2, lymphoid blast crisis-like 1, ARHGEF2, GEF-H1, KIAA0651 or LFP40) is an 894 amino acid GEF for Rho A, a member of the Ras family that regulates the Actin cytoskeleton during the formation of stress fibers. Lfc directly interacts with Cingulin, a junctional adapter that inhibits Rho A, thus preventing phorbol-12-myristate-13-acetate-induced contraction and apoptosis. Mutations in the p53 gene transcriptionally activate Lfc, thereby increasing tumor cell proliferation.Synonyms: GEF-H1, Guanine nucleotide exchange factor H1, KIAA0651, LFP40, Microtubule-regulated Rho-GEF, Proliferating cell nucleolar antigen p40, Rho guanine nucleotide exchange factor 2
Poids moléculaire
approx. 110 kDa
ID gène
9181
NCBI Accession
NP_004714
UniProt
Q92974
Pathways
Negative Regulation of intrinsic apoptotic Signaling
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