IL4 Receptor anticorps

N° du produit ABIN498468

Cet anticorps anti-IL4 Receptor Polyclonal Lapin (ABIN498468) détecte spécifiquement IL4 Receptor dans IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour IL4 Receptor anticorps (ABIN498468)

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL4 Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IL4 Receptor anticorps

Specificité: This antibody detects endogenous levels of IL-4Ralpha protein. (region surrounding Ser254)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur IL4 Receptor

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: CD124 / IL4R

Sujet: The IL-2 receptor is a multicomponent complex consisting of three subunits, alpha, beta and gamma, each of which is required for high affinity binding of IL-2. The alpha chain functions primarily in binding IL-2, whereas the beta and gamma chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2Rgamma chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Ralpha and IL-7Ralpha, respectively, while the common subunit is referred to as gammac. Although the common gamma chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the gammac chain is also a subunit of IL-13R.Synonyms: 582J2.1, IL-4R-alpha, IL4 Receptor alpha, IL4RA, Interleukin-4 receptor alpha chain

Poids moléculaire: approx. 88 kDa

ID gène: 3566

NCBI Accession: NP_000409

UniProt: P24394

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process