Cytokeratin 13 anticorps

N° du produit ABIN498524

Détail du produit anti-Cytokeratin 13 anticorps

Antigène: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cytokeratin 13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Cytokeratin 13 protein. (region surrounding Glu282)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur Cytokeratin 13

Antigène: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Autre désignation: Cytokeratin 13 (KRT13 Produits)

Synonymes: anticorps krt13, anticorps CK13, anticorps K13, anticorps Ka13, anticorps Krt-1.13, anticorps Krt1-13, anticorps ck13, anticorps k13, anticorps keratin 24, anticorps keratin 13, anticorps keratin 13, type I S homeolog, anticorps krt24, anticorps KRT13, anticorps Krt13, anticorps krt13.S, anticorps k13

Sujet: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with Cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epitheli,a and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.Synonyms: CK-13, CK13, K13, KRT-13, KRT13, Keratin type I cytoskeletal 13, Keratin-13

Poids moléculaire: approx. 50 kDa

ID gène: 3860

NCBI Accession: NP_002265

UniProt: P13646