PDGFA anticorps

N° du produit ABIN498533

Détail du produit anti-PDGFA anticorps

Antigène: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDGFA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This detects endogenous levels of PDGF-A protein. (region surrounding Lys154)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur PDGFA

Antigène: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Autre désignation: PDGFA (PDGFA Produits)

Synonymes: anticorps PDGF-A, anticorps PDGF1, anticorps pdgfa, anticorps pdgfa-2, anticorps zgc:100777, anticorps pdgf, anticorps pdgf1, anticorps pdgf-a, anticorps AA409063, anticorps CD142, anticorps Cf-3, anticorps Cf3, anticorps TF, anticorps PDGFACP, anticorps wu:fc32c12, anticorps zgc:153249, anticorps platelet derived growth factor subunit A, anticorps platelet-derived growth factor alpha polypeptide a, anticorps coagulation factor III, anticorps platelet derived growth factor, alpha, anticorps platelet derived growth factor subunit A S homeolog, anticorps platelet-derived growth factor alpha polypeptide b, anticorps PDGFA, anticorps pdgfaa, anticorps pdgfa, anticorps F3, anticorps Pdgfa, anticorps pdgfa.S, anticorps pdgfab

Sujet: PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF-AA, PDGF-AB and PDGF-BB. The three isoforms bind with different affinities to two receptor types, α and β, which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers, the A subunit of PDGF binds only to α receptors with high affinity, whereas the B subunit can bind to both α and β receptors. Evidence suggests that PDGF may function as a neurotrophic factor. The fact that receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons suggests that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system by paracrine and autocrine routes.Synonyms: PDGF A, PDGF alpha, PDGF subunit A, PDGF-1, PDGF-A, PDGF1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha, Platelet-derived growth factor subunit A

Poids moléculaire: approx. 21 kDa

ID gène: 5154

NCBI Accession: NP_002598

UniProt: P04085

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling