Stathmin 1 anticorps (pSer25)

N° du produit ABIN498736

Détail du produit anti-Stathmin 1 anticorps

Antigène: Stathmin 1 (STMN1)

Épitope: pSer25

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Stathmin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Op18 protein only when phosphorylated at Ser25.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS, pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Stathmin 1

Antigène: Stathmin 1 (STMN1)

Autre désignation: Stathmin / STMN1 (STMN1 Produits)

Synonymes: anticorps C1orf215, anticorps LAP18, anticorps Lag, anticorps OP18, anticorps PP17, anticorps PP19, anticorps PR22, anticorps SMN, anticorps 19k, anticorps Lap18, anticorps Op18, anticorps P18, anticorps P19, anticorps Pig, anticorps Pp17, anticorps Pp18, anticorps Pp19, anticorps Pr22, anticorps Smn, anticorps prosolin, anticorps op18, anticorps stathmin, anticorps stmn1, anticorps stmn1a, anticorps lag, anticorps lap18, anticorps pp17, anticorps pp19, anticorps pr22, anticorps smn, anticorps fj43c10, anticorps wu:fj38b07, anticorps wu:fj43c10, anticorps zgc:110159, anticorps cb959, anticorps wu:fb14e04, anticorps zgc:136942, anticorps stmn1-a, anticorps stmn1b, anticorps xo35, anticorps stathmin 1, anticorps stathmin 1 S homeolog, anticorps stathmin 1b, anticorps stathmin 1a, anticorps stathmin-like, anticorps stathmin, anticorps stathmin 1 L homeolog, anticorps STMN1, anticorps Stmn1, anticorps stmn1.S, anticorps stmn1, anticorps stmn1b, anticorps stmn1a, anticorps LOC100229194, anticorps stmn1.L

Sujet: Oncoprotein 18 (Op18) is a regulator of microtubule (MT) dynamics. Op18 is a target for both cell cycle and cell surface receptor-coupled kinase systems, and phosphorylation of Op18 on specific combinations of amino acid residues has been shown to switch off MT-destabilizing activity of Op18. Induced expression of the catalytic subunit of cAMPdependent protein kinase (PKA) results in a dramatic increase in cellular MT polymer content concomitant with phosphorylation and partial degradation of Op18. Phosphorylation of Op18 on two specific sites, Serine 16 and Serine 63, is necessary and sufficient for PKA to switch off Op18 activity in intact cells. PKA phosphorylation down-regulates the MT-destabilizing activity of Op18, which in turn promotes increased Tubulin polymerization. Op18 has the potential to regulate the MT system in response to external signals such as cAMP-linked agonists.Synonyms: LAP18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, Op18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, pp19

Poids moléculaire: approx. 19 kDa

ID gène: 3925

NCBI Accession: NP_005554

UniProt: P16949

Pathways: Signalisation MAPK, Dynamique des Microtubules