NLRP1 anticorps (C-Term)

N° du produit ABIN500310

Cet anticorps anti-NLRP1 est un anticorps Lapin Polyclonal détectant NLRP1 dans WB, IF et EIA. Adapté pour Humain.

Aperçu rapide pour NLRP1 anticorps (C-Term) (ABIN500310)

Antigène: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-NLRP1 anticorps

Épitope: C-Term

Specificité: This antibody detects CARD7 / NLRP1.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: NALP1 antibody was raised against a peptide corresponding to 13 amino acids near the carboxy-terminus of human NALP1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur NLRP1

Antigène: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Autre désignation: CARD7 / NLRP1

Sujet: NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli (1). It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1 (2). Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis (3). NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli (4). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1 (3).Synonyms: Caspase recruitment domain-containing protein 7, DEFCAP, Death effector filament-forming ced-4-like apoptosis protein, KIAA0926, LRR and PYD domains-containing protein 1, NAC, NACHT, NALP1, Nucleotide-binding domain and caspase recruitment domain

ID gène: 22861

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome