NLRP1 anticorps (N-Term)

N° du produit ABIN1169419

Détail du produit anti-NLRP1 anticorps

Antigène: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Épitope: AA 2-25, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Recognizes human NLRP1/NALP1.

Réactivité croisée: Humain

Aucune reactivité croisée: Souris

Réactivité croisée (Details): Does not cross-react with mouse NLRP1/NALP1.

Immunogène: Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) at the N-terminus of human NLRP1/NALP1.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur NLRP1

Antigène: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Autre désignation: NLRP1/NALP1 (NLRP1 Produits)

Synonymes: anticorps CARD7, anticorps CIDED, anticorps CLR17.1, anticorps DEFCAP, anticorps DEFCAP-L/S, anticorps NAC, anticorps NALP1, anticorps PP1044, anticorps SLEV1, anticorps VAMAS1, anticorps NLR family pyrin domain containing 1, anticorps NLRP1, anticorps Nlrp1

Sujet: NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome