DDIT4 anticorps (N-Term)

N° du produit ABIN500644

Cet anticorps Lapin Polyclonal détecte spécifiquement DDIT4 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour DDIT4 anticorps (N-Term) (ABIN500644)

Antigène: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDIT4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-DDIT4 anticorps

Épitope: N-Term

Specificité: This antibody detects DDIT4 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: RTP801 antibody was raised against a 14 amino acid peptide from near the amino terminus of human DDIT4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur DDIT4

Antigène: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Autre désignation: DDIT4

Sujet: RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.Synonyms: DDIT-4, DNA-damage-inducible transcript 4, Dig2, HIF-1 responsive protein, Protein regulated in development and DNA damage response 1, REDD-1, REDD1, RTP801

ID gène: 54541

NCBI Accession: NP_061931

UniProt: Q9NX09

Pathways: Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process