PLC gamma 1Tyr775 (pTyr775) anticorps (Alexa Fluor 680)

N° du produit ABIN5008951

Détail du produit

Antigène: PLC gamma 1Tyr775

Épitope: pTyr775

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Alexa Fluor 680

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PLC gamma 1 around the phosphorylation site of Tyr775

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: PLC gamma 1Tyr775

Sujet:

Synonyms: PLCG1phospho Y775, PLC 1, PLC 148, PLC gamma 1, PLC II, PLC1, PLC148, PLCG 1, PLCG1, PLCgamma1, PLCII, triphosphoinositide phosphodiesterase, 1 phosphatidyl D myo inositol 4 5 bisphosphate, 1 phosphatidylinositol 4 5 bisphosphate, 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, phosphodiesterase gamma 1, phosphoinositidase C, phosphoinositide phospholipase C, Phospholipase C 148, phospholipase C gamma 1 formerly subtype 148, Phospholipase C gamma 1, phospholipase C-148, PLCG1_HUMAN.

Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ID gène: 5335