PLEKHM1 anticorps (AA 546-700) (Alexa Fluor 680)
-
- Antigène Voir toutes PLEKHM1 Anticorps
- PLEKHM1 (Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1))
-
Épitope
- AA 546-700
- Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp PLEKHM1 est conjugé à/à la Alexa Fluor 680
-
Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human PLEKHM1
- Isotype
- IgG
- Top Product
- Discover our top product PLEKHM1 Anticorps primaire
-
-
- Indications d'application
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- PLEKHM1 (Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1))
- Autre désignation
- PLEKHM1 (PLEKHM1 Produits)
- Synonymes
- anticorps AP162, anticorps B2, anticorps OPTB6, anticorps BC038943, anticorps D330036J23Rik, anticorps pleckstrin homology and RUN domain containing M1, anticorps pleckstrin homology domain containing, family M (with RUN domain) member 1, anticorps PLEKHM1, anticorps Plekhm1
- Sujet
-
Synonyms: 162 kDa adapter protein, AP162, PH domain-containing family M member 1, PKHM1_HUMAN, Pleckstrin homology domain-containing family M member 1, PLEKHM1.
Background: Involved in vesicular transport in the osteoclast (By similarity). May have a role in sialyl-lex-mediated transduction of apoptotic signals.Tissue specificity: Expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine. Predominantly expressed in the breast carcinoma cell line MCF-7.Involvement in disease:Defects in PLEKHM1 are the cause of osteopetrosis autosomal recessive type 6 (OPTB6), also known as autosomal recessive osteopetrosis intermediate form. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts.
- ID gène
- 9842
-