TLR4 anticorps (N-Term)

N° du produit ABIN500952

Détail du produit anti-TLR4 anticorps

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects CD284 / TLR4 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Ion exchange chromatography

Immunogène: TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of human TLR4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2 to 5 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TLR4

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Autre désignation: CD284 / TLR4 (TLR4 Produits)

Synonymes: anticorps ARMD10, anticorps CD284, anticorps TLR-4, anticorps TOLL, anticorps Lps, anticorps Ly87, anticorps Ran/M1, anticorps Rasl2-8, anticorps toll like receptor 4, anticorps toll-like receptor 4, anticorps TLR4, anticorps Tlr4

Sujet: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappaB (4-6). Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis (7).Synonyms: Toll-like receptor 4

ID gène: 7099

NCBI Accession: NP_612564

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins