DACT1 anticorps (AA 645-820)

N° du produit ABIN5027132

Détail du produit anti-DACT1 anticorps

Antigène: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Épitope: AA 645-820

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DACT1 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant Dapper homolog 1 protein (amino acids 645-820) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur DACT1

Antigène: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Autre désignation: Dapper homolog 1 (DACT1 Produits)

Synonymes: anticorps XDpr, anticorps dpr1, anticorps frodo, anticorps hdpr1, anticorps Dapper, anticorps thyex3, anticorps dapper1, anticorps MGC89695, anticorps frd1, anticorps frodo1, anticorps 4921528D17Rik, anticorps AI115603, anticorps DAPPER, anticorps DAPPER1, anticorps FRODO, anticorps Frd1, anticorps Frodo1, anticorps MDpr1, anticorps MTNG3, anticorps THYEX3, anticorps DPR1, anticorps HDPR1, anticorps DACT1, anticorps RGD1564008, anticorps XDpr1a, anticorps dact1, anticorps dpr, anticorps XDpr1b, anticorps dishevelled-binding antagonist of beta-catenin 1, anticorps dishevelled binding antagonist of beta catenin 1, anticorps dishevelled-binding antagonist of beta-catenin 1 L homeolog, anticorps dishevelled-binding antagonist of beta-catenin 1 S homeolog, anticorps dact1, anticorps Dact1, anticorps DACT1, anticorps dact1.L, anticorps dact1.S

Sujet: Dapper homolog 1 (DACT1) is a cytoplasmic protein and a member of DACT family. It is an important regulator in the planar cell polarity (PCP) pathway. DACT1 interacts and posttranslationally regulates central PCP components Dvl2 and Vangl2 and modulates PCP downstream of the Rac1/JNK cascade. The gene for DACT1 is located at chromosome 14q22.3, which encodes a 836 amino acid protein with a putative leucine zipper (LZ) domain in the amino-terminal end and a consensus PDZ binding (PDZ-B) motif in the carboxy-terminal end that allows the DACT1 protein to interact with the Dishevelled (Dvl) PDZ domain. DACT1 is an important positive regulator in colon cancer through regulating the stability and sublocation of Beta-catenin. The overexpression of DACT1 leads to the increased accumulation of nonphosphorylated Beta-catenin in the cytoplasm and particularly in the nuclei.It interacts with GSK-3beta and beta-catenin and stabilizes it via DACT1-induced effects on GSK-3beta which directly interacts with beta-catenin proteins. This interaction identifies DACT1 as an important positive regulator in colon cancer and suggests a potential strategy for the therapeutic control of the beta-catenin-dependent pathway.

Poids moléculaire: 92 kDa

ID gène: 51339

UniProt: Q9NYF0

Pathways: Positive Regulation of fat Cell Differentiation