TFG anticorps (AA 196-400)

N° du produit ABIN5027602

Détail du produit anti-TFG anticorps

Antigène: TFG (Trk-Fused Gene (TFG))

Épitope: AA 196-400

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFG est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant TRK Fused gene protein (amino acids 196-400) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB:1-2 μg/mL, IHC: 20 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur TFG

Antigène: TFG (Trk-Fused Gene (TFG))

Autre désignation: TRK Fused gene (TFG Produits)

Synonymes: anticorps wu:fb11c10, anticorps zgc:55342, anticorps zgc:77230, anticorps HMSNP, anticorps SPG57, anticorps TF6, anticorps TRKT3, anticorps AI173908, anticorps trk-fused gene, anticorps TRK-fused gene, anticorps Trk-fused gene, anticorps tfg, anticorps TFG, anticorps Tfg

Sujet: TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation.

Poids moléculaire: 50 kDa

ID gène: 10342

UniProt: Q92734