BST2 anticorps

N° du produit ABIN5027752

Détail du produit anti-BST2 anticorps

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BST2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: Protein G Chromatography

Immunogène: Full length recombinant protein of BST 2 was used as the immunogen for this antibody.

Clone: ABM52D8

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, FACS: 0.5-1 μg/10^6

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur BST2

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Autre désignation: BST 2 (BST2 Produits)

Synonymes: anticorps BST2, anticorps CD317, anticorps TETHERIN, anticorps 2310015I10Rik, anticorps Bst-2, anticorps C87040, anticorps DAMP-1, anticorps GREG, anticorps Damp1, anticorps bone marrow stromal cell antigen 2, anticorps bone marrow stromal antigen 2, anticorps BST2, anticorps LOC618737, anticorps Bst2

Sujet: BST2 (Bone Marrow Stromal Antigen 2), a type II transmembrane protein also known as HM1.24/CD317, has been identified to be overexpressed in a variety of cell lines from different cancer types, including multiple myeloma, breast, lung, and kidney cancers. BST2 was discovered as a marker of differentiated B cells and was later rediscovered as a potent antiviral restriction factor with the ability to tether enveloped viruses to the cell membrane of infected cells via its GPI anchor as well as to potently inhibit virus replication in cultured cells and in vivo. It also acts as an innate immune sensor of HIV-1 that elicits an inflammatory response upon exposure. BST2 mediate host immune response by activating NF-KB through interaction with TAK1 (Transforming Growth Factor Beta-Activated Kinase 1) and TNF receptor associated factors (TRAFs) 2 and 6. In addition, BST2 induces ADCC (antibody-dependent cell cytotoxicity) against the envelope protein of HIV. BST2 was expressed constitutively on the cell surface of both CD3- and CD3+ thymocytes ex vivo.

Poids moléculaire: 17 kDa

ID gène: 684

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response