TLR4 anticorps (APC)
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- Antigène Voir toutes TLR4 Anticorps
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TLR4 est conjugé à/à la APC
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Application
- Flow Cytometry (FACS)
- Purification
- Protein G Chromatography
- Immunogène
- This antibody was developed by immunizing mice with Ba/F3 cell line expressing human TLR4 cell surface antigen.
- Clone
- HTA125
- Isotype
- IgG2a
- Top Product
- Discover our top product TLR4 Anticorps primaire
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- Indications d'application
- FACS: 0.5-1 μg/10^6
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months.
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- Antigène
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Autre désignation
- TLR4 (TLR4 Produits)
- Synonymes
- anticorps ARMD10, anticorps CD284, anticorps TLR-4, anticorps TOLL, anticorps Lps, anticorps Ly87, anticorps Ran/M1, anticorps Rasl2-8, anticorps toll like receptor 4, anticorps toll-like receptor 4, anticorps TLR4, anticorps Tlr4
- Sujet
- TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.
- ID gène
- 7099
- UniProt
- O00206
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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