C14orf169 + NO66 anticorps (Middle Region)

N° du produit ABIN5514591

Détail du produit anti-C14orf169 + NO66 anticorps

Antigène: C14orf169 + NO66 (C14orf169) (Chromosome 14 Open Reading Frame 169 (C14orf169))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C14orf169 + NO66 est non-conjugé

Application: Western Blotting (WB)

Séquence: EAILPLAVQA AMEENVEFRR GLPRDFMDYM GAQHSDSKDP RRTAFMEKVR

Attributs du produit: This is a rabbit polyclonal antibody against NO66. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human NO66

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur C14orf169 + NO66

Antigène: C14orf169 + NO66 (C14orf169) (Chromosome 14 Open Reading Frame 169 (C14orf169))

Autre désignation: NO66 (C14orf169 Produits)

Synonymes: anticorps LOC453015, anticorps C10H14orf169, anticorps MAPJD, anticorps NO66, anticorps ROX, anticorps C14orf169, anticorps No66, anticorps im:7141580, anticorps no66, anticorps chromosome 14 open reading frame 169, anticorps ribosomal oxygenase 1, anticorps chromosome 5 open reading frame, human C14orf169, anticorps LOC453015, anticorps Bm1_08415, anticorps RIOX1, anticorps C5H14ORF169, anticorps Riox1, anticorps riox1

Sujet: NO66 is an oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically It demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). It also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). It may also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region.

Alias Symbols: NO66, C14orf169, MAPJD,

Protein Interaction Partner: KAT5, TRRAP, MYC, USP42,

Protein Size: 429

ID gène: 79697