Cathepsin B anticorps (Middle Region)

N° du produit ABIN5514606

Détail du produit anti-Cathepsin B anticorps

Antigène: Cathepsin B (CTSB)

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin B est non-conjugé

Application: Western Blotting (WB)

Séquence: HHVNGSRPPC TGEGDTPKCS KICEPGYSPT YKQDKHYGYN SYSVSNSEKD

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CTSB

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Cathepsin B

Antigène: Cathepsin B (CTSB)

Autre désignation: CTSB (CTSB Produits)

Synonymes: anticorps APPS, anticorps CPSB, anticorps CB, anticorps apps, anticorps cpsb, anticorps LOC692390, anticorps CTSB, anticorps cathepsin B, anticorps cathepsin B S homeolog, anticorps CTSB, anticorps Ctsb, anticorps ctsb.S, anticorps LOC692390

Sujet: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified.

Alias Symbols: APPS, CPSB

Protein Size: 339

ID gène: 1508

NCBI Accession: NM_001908, NP_001899

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades