MKRN1 anticorps (C-Term)

N° du produit ABIN5514960

Détail du produit anti-MKRN1 anticorps

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKRN1 est non-conjugé

Application: Western Blotting (WB)

Séquence: SRYRAQRRNH FWELIEEREN SNPFDNDEEE VVTFELGEML LMLLAAGGDD

Attributs du produit: This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MKRN1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MKRN1

Antigène: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Autre désignation: MKRN1 (MKRN1 Produits)

Synonymes: anticorps MKRN1, anticorps MGC84269, anticorps mkrn1, anticorps Makorin-1, anticorps RNF61, anticorps RFP, anticorps makorin ring finger protein 1, anticorps E3 ubiquitin-protein ligase makorin-1, anticorps makorin ring finger protein 1 S homeolog, anticorps makorin, ring finger protein, 1, anticorps MKRN1, anticorps LOC100393879, anticorps mkrn1.S, anticorps Mkrn1

Sujet: This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: RNF61

Protein Size: 482

ID gène: 23608

NCBI Accession: NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding